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3Sep/100

From Bethlem to Bedlam

18th-century Bethlem – chains, belts, purges, bleeding and thousands of visitors gawping at the inmates. Nell Leyshon on the asylum that inspired her latest play

My new play, Bedlam, about to open at the Globe, is set in a fictionalised Bethlem, in the mid-18th century, a time when psychiatry had yet to be born, and London was still enthralled with gin.

Bethlem's name gave rise to the word bedlam, and comes from a shortened version of St Mary Bethlehem, the name of one of the oldest asylums in the western world. It has been the subject of many plays and texts, from Shakespeare through the restoration comedies, up to the crazes in the 17th and 18th centuries for popular songs. Although there were many private, unregulated madhouses, where terrible cruelties and injustices took place – where it was possible to get rid of an inconvenient wife, or an illegitimate child – it was Bethlem that came to represent the notion of the asylum, and indeed madness.

The hospital was feared for good reason. The treatment was barbaric – bleeding, purges to make patients vomit, cold baths – and until 1770 the public were allowed into the asylum to view (and provoke) the patients. The scale of these visits were breathtaking: every week more than 2,000 visitors were free to wander through the wards, and mix with the patients, whose nurses and keepers would parade them and get them to "perform".

In theory, the visits were to have two impacts: the public would learn a moral lesson and henceforth curb their own behavioural excesses, and they would learn the act of charitable giving. In reality they attracted all of society, from London's fashionable to London's lowlife, most of whom drank and made sport for the day.

I started my research by reading Roy Porter's works on the social history of asylums and mad doctors, as well as histories of gin, books on the staffing structure of Bethlem and a dictionary of vulgar language. There's a great comfort in immersion in another world before beginning to write, but its seductive quality eventually becomes a delaying tactic. So I closed my books and faced the fact that Bedlam, now Bethlem Royal Hospital in Kent, still exists. My first visit was to the archives, looking at the original records, including colourful accounts of staff meetings and admissions and discharges. The pages are peopled with untold stories and summaries of difficult lives, written in a few copperplate lines. I also visited the museum, which displays the old restraints: chains, early straitjackets, leather mouthpieces, belts with cuffs. It also has a world-class collection of psychiatric art containing some disturbing attempts to illuminate the reality of the mad inner world, with work by Richard Dadd and Louis Wain, as well as some moving paintings by women in the 20th century.

On my second visit I met the forensic psychiatrist, Dr Tim McInerny, and his patients. I went to River House, a medium-secure unit for patients who had committed crimes while mentally ill. The men talked with great lucidity and intelligence about the humiliation and loneliness of madness. They described the reality of what it is to suffer an illness so severe that it may cause you, in a state of psychosis, to murder the people you love the most. They explained that they remembered everything they had done while ill, and much of the hospital's work is an attempt to help them come to terms with the crimes they committed.

After talking for a while, we discussed the infamous open days. The patients told me they still felt observed, and that their madness meant they led public lives. The staff observed them, visiting experts observed them – Bethlem is now at the forefront of humanitarian treatment – and indeed, as one patient pointed out, I too was a voyeur. Another patient described how their behaviour was constantly monitored and if they wanted to be allowed out, they had to learn what was "acceptable". He described himself as a highly trained circus animal.

The patients offered to read the play, and they will be coming to the Globe to see it. They also met the director, Jessica Swale, and the actors who will represent the 18th-century patients. But there was one uncomfortable question I had yet to raise. Representations of Bethlem have always invoked not only pity but humour. I asked the patients if I was free to make the play funny. They all said yes, they would prefer it if I did. The wards were full of misery, but there was much humour, too, shared with the staff.

Madness has a particular attraction for a writer. Dialogue involves what is unsaid as much as what is said. The actor fills in body language, and the audience's role is to work out from the words spoken, what thought patterns lie behind. Drama becomes exciting when the words spoken and the words unsaid are at odds, and we become aware of deep undercurrents. When madness is portrayed, each line of dialogue can be rational and reasonable; it is the thought behind the lines which is not.

We no longer believe madness is a matter of possession by another spirit, and we know it is not a moral "choice" or an imbalance of the humours. We know some things, that a family propensity or an extreme experience can take us into new territories of depression or mania. We know that everyone is open to it. It is the great leveller, and reduces to meaningless all human endeavour and gain. Money and standing become irrelevant.

The word madness means everything: it can take your power away from you, can lead you to being locked up against your will. But it also means nothing. It is only a word used to describe a vast amount of human experience, from the heights of joy and creative thinking that mania can enable, to the depths of catatonic misery. The dark state of madness is still one place left to be fully discovered.

Bedlam by Nell Leyshon is at Shakespeare's Globe from tomorrow to 1 October 2010. Bethlem Hospital Archives and Museum, www.bethlemheritage.org.uk


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From Bethlem to Bedlam

3Sep/100

Hormone in Hair May Reveal Heart Risk

High levels of cortisol in the hair shaft may increase the risk of heart attack, a study shows.

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3Sep/100

SAM-e May Boost Effects of Antidepressants

SAM-e plus prescription antidepressants may spell relief for hard-to-treat depression, according to a new study.

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3Sep/100

Does Depression Cause Weight Gain or Weight Gain? What’s the Depression/Weight Connection?

Does depression cause weight gain or weight loss? Does weight gain or weight loss cause depression? WebMD helps to unravel the mystery surrounding the link between depression and weight.

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3Sep/100

Too Sick to Work?

You wake up feeling crummy. Should you drag yourself to work and risk infecting coworkers? Or should you phone in sick, even though your boss desperately needs you to pitch in during a stressful week?

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3Sep/100

The joy of sobriety | Mary Kenny

I'm glad to see alcohol consumption fall – but how about some pro-sobriety messages instead of the usual anti-drink nagging?

I stopped drinking almost 20 years ago, and I sometimes think that my real life began on that day in 1991. Getting sober was one of the best things I ever did, and, strangely, one of the most liberating. Drinking was one of the worst things I did, and I did it continuously and abusively from the age of 18 into my late 40s.

It's obvious that alcohol can enhance pleasure and conviviality, taken moderately; it can also bring people together in a warm and supportive way. The local pub is a great institution and a social lifeline for many. In my misspent youth, both in London and in Dublin, it was also a location of some great conversations, terrific stories and legendary characters. But for many who drift into problem boozing, alcohol represents a trail of disasters, a ghastly series of flashback of bad memories, horrible embarrassments and near-lethal experiences. (I owe my survival to the poet Derek Mahon: he physically stopped me from driving a car when hopelessly plastered back in the 1980s.)

So I am really glad that alcohol consumption has fallen once again this year – and this trend seems now to be established. Because that's a step towards changing the culture of drinking, which can be such a snare for alcohol abusers. Many of the campaigns against alcohol focus on the damage that it can do – that it harms your liver, can be a factor in throat and bladder cancers, and wrecks your personal and professional life. All this is true, but it's emphasising the negative: what about stressing the joy of sobriety?

I once thought that life couldn't be fully experienced without alcohol: but the truth is the opposite – life can be more fully experienced without alcohol. Drunkenness deadens experience: it renders delight oblivious and pleasure dull. Although I get anguished flashbacks from my drinking years, I have also forgotten huge tranches of my life. Regrets are pointless, but it is sad that I lost so much of the prime of my life in that haze of alcoholic amnesia.

And then, sobriety turned out to be the true champagne – bringing everything into focus in clear colour and full recall. One of the strangest things that happened to me after I started getting sober was that I had this intense sensation of colour all around me. The colours of life became so heightened.

We seem to be so nagged at and scolded about so many health and safety issues that I am not sure if gloomy warnings about the health dangers of alcohol are all that effective. Two things clearly help: increase the price of dirt-cheap supermarket alcohol, and emphasise the pleasures of sobriety. Justin Webb wrote recently about an experience he had in America – which appalled him – when he went to a smart Washington party, only to find that the "punch" being served was cherryade. I thought, "Bravo for the hosts". American culture, for all its faults, does not have this general idea that you have to be plastered to have fun. Honestly – you can have a great time on cherryade. Well, preferably, elderflower spritzer.

Searching for a birthday card, recently, for a young relation who was turning 21, I was hard put to find any greetings card aimed at young men which didn't emphasise the glory of getting pissed. But getting pissed isn't glorious: it's shaming. It is life, fully savoured, fully aware, that is the glorious intoxicant.

Mary Kenny


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3Sep/100

G20 pathologist Freddy Patel suspended for misconduct

Disciplinary panel suspends pathologist, who carried out first post-mortem examination on Ian Tomlinson, for three months

The pathologist who carried out the first post-mortem examination on newspaper seller Ian Tomlinson, who died at the G20 protests, was today suspended from the medical register for three months.

A General Medical Council disciplinary panel previously ruled that Dr Freddy Patel acted in a way that amounted to misconduct in two earlier post-mortem examinations, meaning his fitness to practise was impaired.

The panel also ruled that Patel had displayed deficient professional performance in a third examination.

He has already been suspended from the Home Office register of forensic pathologists after questions were asked about the autopsy carried out on the body of 47-year-old Tomlinson, who died in London in April last year.

The panel had already concluded that Patel was "irresponsible" and failed to meet professional standards during his examinations of the bodies of a five-year-old girl in 2002, a four-week-old baby in 2003 and a woman who died in 2005.

Patel, 63, behaved irresponsibly, failed to meet standards expected of a Home Office pathologist, and acted in a way liable to bring the profession into disrepute when he changed the woman's cause of death in 2005, the panel found.

He carried out a post-mortem examination on 5 January 2005, and decided she had died due to a blood clot in the coronary arteries.

A month later, after a second examination by another pathologist, he prepared an addendum to his report, changing the cause of death to a brain haemorrhage in line with the new findings.

Patel told an inquest into the woman's death he had changed the primary cause of death "to satisfy the family".

But the panel chairman, Richard Davies, said the pathologist's assumption that, as the death was not suspicious, the change made no difference from the coroner's viewpoint and merely allowed an inquest to proceed was not an adequate explanation.

In the GMC ruling, Davies said Patel's "acts and omissions were very serious" and amounted to misconduct.

He said pathologists "must not set aside their professional judgement for any of the parties involved during or after a post-mortem examination for reasons of expediency or anything else".

Patel's failure to note the weights of individual organs examined, as is recommended by Royal College of Pathologists' guidance, showed deficient professional performance.

Patel was also found to be guilty of misconduct in a post-mortem examination on the four-week-old baby in August 2003.


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3Sep/100

Pubs cite record fall in alcohol drinking

British Beer and Pub Association said 2009 saw the sharpest decline in alcohol consumption since 1948

The UK has seen its biggest fall in alcohol consumption in 60 years, according to new figures from an industry body.

The British Beer and Pub Association (BBPA) said 2009 saw the sharpest year-on-year decline in alcohol consumption across the board since 1948.

The figures are compiled primarily from HM Revenue and Customs data for the amount of alcohol sold by producers and importers into the UK market.

They follow recent data from the Office of National Statistics that found 39% of men and 31% of women exceed the daily guidelines on how much they should drink.

The BBPA, which represents the brewing and pub sector, said the data showed a 6% decline in total alcohol consumption in 2009, making it the fourth annual decline in five years.

UK drinkers were now consuming 13% less alcohol than in 2004, with consumption remaining below the EU average.

British taxes on beer remained among the highest compared with other countries and were the second highest duty rate in EU – 10 times higher than in Germany and seven times higher than in France, the organisation said.

Other statistics published in the BBPA Statistical Handbook 2010 show beer is by far the pub-goer's favourite tipple, making up 60% of all alcohol sales in pubs, hotels, and restaurants. Wine is in second place at 17%.

Total spending on beer has reached £17bn a year, or 41% of all spending on alcohol.

The average price of a pint of bitter is £2.58, with lager selling for £2.95.

London is the most expensive region to buy a pint, with prices 35% higher than in the north-east.

The BBPA chief executive, Brigid Simmonds, said: "These figures will confound many pundits as yet again they confirm that as a nation we are not drinking more. Those who suggest otherwise need to focus on the hard facts.

"This handbook also reminds us of just how vital a role beer and pubs play in the UK economy in terms of turnover, jobs, and tax revenues.

"The new numbers show just how closely linked beer is to Britain's struggling pubs, with beer accounting for around 60% of on-trade sales. Policy makers should take note."


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3Sep/100

Study cautions over longterm use of osteoporosis drugs and cancer risk

Regulatory agency says findings should not stop medicinal use of oral bisphosphonates

Longterm use of drugs that are commonly prescribed for osteoporosis may be doubling the users' risk of developing cancer of the oesophagus, a study warns.

The drugs are routinely used to either treat or prevent osteoporosis and other bone conditions and are taken by many hundreds of thousands of patients.

Research in today's British Medical Journal links the use of oral bisphosphonates to an increased risk of getting one of the more severe forms of cancer, although no links were found to stomach or bowel cancer.

Experts from the University of Oxford's cancer epidemiology unit and the government's Medicines and Healthcare products Regulatory Agency (MHRA) analysed data from a UK GP practice database on around 6 million people.

Among those aged 40 and over, 2,954 had oesophageal cancer, 2,018 had gastric cancer and 10,641 had bowel cancer, all diagnosed between 1995 and 2005.

Examination of their health records showed that the chance of oesophageal cancer was 30% higher in people who had had one or more previous prescriptions for oral bisphosphonates, compared with people who had never taken the drugs.

The risk was almost double for those who had 10 or more prescriptions, compared with those who had had less than 10. And for those taking the drugs for at least three years – five years on average – the risk was more than double compared with those who had never had a prescription for the drugs.

Typically, oesophageal cancer develops in one per 1,000 people aged 60 to 79 over five years. Use of oral bisphosphonates over five years would push this up to two cases per 1,000 people, the authors said.

The main author, Dr Jane Green, said: "Oesophageal cancer is uncommon. The increased risks we found were in people who used oral bisphosphonates for about five years, and even if our results are confirmed, few people taking bisphosphonates are likely to develop oesophageal cancer as a result of taking these drugs.

"Our findings are part of a wider picture. Bisphosphonates are being increasingly prescribed to prevent fractures, and what is lacking is reliable information on the benefits and risks of their use in the long-term."

Each year, around 8,000 people in the UK are diagnosed with the disease and around 7,500 people die from it.

An MHRA spokesman said the findings should not stop patients from taking their bisphosphonate medicine. He said the UK Commission on Human Medicines had advised that the evidence from the study was not strong enough to suggest a definite causal association between oral bisphosphonates and oesophageal cancer. However in order to reduce risk of oesophageal irritation it is important to carefully follow the instructions.

The spokesman added: "Patients should also report any signs of oesophageal irritation such as difficulties or pain on swallowing, chest pain, or heartburn to their doctor."

Recent studies have suggested no link between the drugs and oesophageal cancer, but it is thought the drugs do protect against breast cancer in post-menopausal women.

Denis Campbell


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3Sep/100

Osteoporosis Drugs May Be Linked to Cancer Risk

The long-term use of oral bisphosphonate osteoporosis drugs such as Actonel, Boniva, and Fosamax may be associated with a doubling in esophageal cancer risk, but the risk to individual users remains small, researchers say.

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Osteoporosis Drugs May Be Linked to Cancer Risk

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